Details of the Target

General Information of Target

Target ID LDTP15105
Target Name KN motif and ankyrin repeat domain-containing protein 3 (KANK3)
Gene Name KANK3
Gene ID 256949
Synonyms
ANKRD47; KN motif and ankyrin repeat domain-containing protein 3; Ankyrin repeat domain-containing protein 47
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAAAGDADDEPRSGHSSSEGECAVAPEPLTDAEGLFSFADFGSALGGGGAGLSGRASGG
AQSPLRYLHVLWQQDAEPRDELRCKIPAGRLRRAARPHRRLGPTGKEVHALKRLRDSANA
NDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPL
HLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAVRLEVKQ
IIHMLREYLERLGQHEQRERLDDLCTRLQMTSTKEQVDEVTDLLASFTSLSLQMQSMEKR
Target Bioclass
Other
Function May be involved in the control of cytoskeleton formation by regulating actin polymerization.
Uniprot ID
Q6NY19
Ensemble ID
ENST00000330915.7
HGNC ID
HGNC:24796

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C684(1.53)  LDD3382  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0371  CL102 HEK-293T C684(0.77)  LDD1575  [2]
 LDCM0375  CL106 HEK-293T C684(0.57)  LDD1579  [2]
 LDCM0380  CL110 HEK-293T C684(1.10)  LDD1584  [2]
 LDCM0384  CL114 HEK-293T C684(0.95)  LDD1588  [2]
 LDCM0388  CL118 HEK-293T C684(1.26)  LDD1592  [2]
 LDCM0393  CL122 HEK-293T C684(0.71)  LDD1597  [2]
 LDCM0397  CL126 HEK-293T C684(0.89)  LDD1601  [2]
 LDCM0401  CL14 HEK-293T C684(0.97)  LDD1605  [2]
 LDCM0407  CL2 HEK-293T C684(0.08)  LDD1611  [2]
 LDCM0414  CL26 HEK-293T C684(4.30)  LDD1618  [2]
 LDCM0441  CL50 HEK-293T C684(0.82)  LDD1645  [2]
 LDCM0454  CL62 HEK-293T C684(0.87)  LDD1657  [2]
 LDCM0467  CL74 HEK-293T C684(1.06)  LDD1670  [2]
 LDCM0480  CL86 HEK-293T C684(0.82)  LDD1683  [2]
 LDCM0493  CL98 HEK-293T C684(0.71)  LDD1696  [2]
 LDCM0427  Fragment51 HEK-293T C684(0.85)  LDD1631  [2]
 LDCM0022  KB02 A673 C684(1.29)  LDD2261  [1]
 LDCM0023  KB03 IGROV-1 C684(2.02)  LDD2815  [1]
 LDCM0024  KB05 OVCAR-4 C684(1.53)  LDD3382  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402