Details of the Target

General Information of Target

Target ID LDTP15089
Target Name Follistatin-related protein 4 (FSTL4)
Gene Name FSTL4
Gene ID 23105
Synonyms
KIAA1061; Follistatin-related protein 4; Follistatin-like protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSAPNGRKKRPSRSTRSSIFQISKPPLQSGDWERRGSGSESAHKTQRALDDCKMLVQEF
NTQVALYRELVISIGDVSVSCPSLRAEMHKTRTKGCEMARQAHQKLAAISGPEDGEIHPE
ICRLYIQLQCCLEMYTTEMLKSICLLGSLQFHRKGKEPGGGTKSLDCKIEESAETPALED
SSSSPVDSQQHSWQVSTDIENTERDMREMKNLLSKLRETMPLPLKNQDDSSLLNLTPYPL
VRRRKRRFFGLCCLISS
Target Bioclass
Immunoglobulin
Subcellular location
Secreted
Uniprot ID
Q6MZW2
Ensemble ID
ENST00000265342.12
HGNC ID
HGNC:21389

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO320 SNV: p.A517P .
DU145 SNV: p.D760Y .
FTC133 SNV: p.D166Y .
HT29 SNV: p.V127I .
IGR1 SNV: p.M369I .
IGROV1 Deletion: p.G790VfsTer6 .
JHH7 SNV: p.A19P .
KMCH1 SNV: p.S256R .
LNCaP clone FGC Deletion: p.G790VfsTer6
SNV: p.H638Y		 .
LOXIMVI SNV: p.S56F .
NCIH1650 SNV: p.Ter843CextTer51 .
NCIH1703 SNV: p.K616M .
NCIH1793 SNV: p.P696A .
NCIH2172 SNV: p.G802V .
RKO Deletion: p.G790VfsTer6 .
SW480 SNV: p.K149R .
TF1 SNV: p.E423V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C642(1.03)  LDD2157  [1]
1d-yne
 Probe Info  		N.A.  LDD0357  [2]
Acrolein
 Probe Info  		C119(0.00); H58(0.00)  LDD0217  [3]

References

1 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
2 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.