Details of the Target

General Information of Target

Target ID LDTP15083
Target Name NADH-cytochrome b5 reductase-like (CYB5RL)
Gene Name CYB5RL
Gene ID 606495
Synonyms
NADH-cytochrome b5 reductase-like; EC 1.6.2.2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDRSAEFRKWKAQCLSKADLSRKGSVDEDVVELVQFLNMRDQFFTTSSCAGRILLLDRGI
NGFEVQKQNCCWLLVTHKLCVKDDVIVALKKANGDATLKFEPFVLHVQCRQLQDAQILHS
MAIDSGFRNSGITVGKRGKTMLAVRSTHGLEVPLSHKGKLMVTEEYIDFLLNVANQKMEE
NKKRIERFYNCLQHALERETMTNLHPKIKEKNNSSYIHKKKRNPEKTRAQCITKESDEEL
ENDDDDDLGINVTIFPEDY
Target Bioclass
Enzyme
Family
Flavoprotein pyridine nucleotide cytochrome reductase family
Function NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
Uniprot ID
Q6IPT4
Ensemble ID
ENST00000287899.13
HGNC ID
HGNC:32220

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HUH7 SNV: p.V216F .
NCIH1299 SNV: p.L231F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C68(1.40)  LDD1571  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0367  CL1 HEK-293T C68(1.40)  LDD1571  [1]
 LDCM0370  CL101 HEK-293T C68(1.04)  LDD1574  [1]
 LDCM0371  CL102 HEK-293T C68(1.12)  LDD1575  [1]
 LDCM0374  CL105 HEK-293T C68(1.37)  LDD1578  [1]
 LDCM0375  CL106 HEK-293T C68(0.86)  LDD1579  [1]
 LDCM0378  CL109 HEK-293T C68(1.09)  LDD1582  [1]
 LDCM0380  CL110 HEK-293T C68(1.07)  LDD1584  [1]
 LDCM0383  CL113 HEK-293T C68(1.44)  LDD1587  [1]
 LDCM0384  CL114 HEK-293T C68(1.19)  LDD1588  [1]
 LDCM0387  CL117 HEK-293T C68(1.14)  LDD1591  [1]
 LDCM0388  CL118 HEK-293T C68(1.04)  LDD1592  [1]
 LDCM0392  CL121 HEK-293T C68(1.04)  LDD1596  [1]
 LDCM0393  CL122 HEK-293T C68(1.13)  LDD1597  [1]
 LDCM0396  CL125 HEK-293T C68(1.34)  LDD1600  [1]
 LDCM0397  CL126 HEK-293T C68(1.02)  LDD1601  [1]
 LDCM0400  CL13 HEK-293T C68(1.42)  LDD1604  [1]
 LDCM0401  CL14 HEK-293T C68(0.94)  LDD1605  [1]
 LDCM0407  CL2 HEK-293T C68(1.09)  LDD1611  [1]
 LDCM0413  CL25 HEK-293T C68(1.08)  LDD1617  [1]
 LDCM0414  CL26 HEK-293T C68(1.09)  LDD1618  [1]
 LDCM0426  CL37 HEK-293T C68(1.26)  LDD1630  [1]
 LDCM0439  CL49 HEK-293T C68(1.26)  LDD1643  [1]
 LDCM0441  CL50 HEK-293T C68(0.83)  LDD1645  [1]
 LDCM0453  CL61 HEK-293T C68(1.21)  LDD1656  [1]
 LDCM0454  CL62 HEK-293T C68(1.18)  LDD1657  [1]
 LDCM0466  CL73 HEK-293T C68(1.12)  LDD1669  [1]
 LDCM0467  CL74 HEK-293T C68(0.97)  LDD1670  [1]
 LDCM0479  CL85 HEK-293T C68(1.31)  LDD1682  [1]
 LDCM0480  CL86 HEK-293T C68(0.92)  LDD1683  [1]
 LDCM0492  CL97 HEK-293T C68(1.48)  LDD1695  [1]
 LDCM0493  CL98 HEK-293T C68(1.28)  LDD1696  [1]
 LDCM0427  Fragment51 HEK-293T C68(0.74)  LDD1631  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402