Details of the Target

General Information of Target

Target ID LDTP15074
Target Name Zinc finger protein 470 (ZNF470)
Gene Name ZNF470
Gene ID 388566
Synonyms
CZF1; Zinc finger protein 470; Chondrogenesis zinc finger protein 1; CZF-1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEHTHAHLAANSSLSWWSPGSACGLGFVPVVYYSLLLCLGLPANILTVIILSQLVARRQK
SSYNYLLALAAADILVLFFIVFVDFLLEDFILNMQMPQVPDKIIEVLEFSSIHTSIWITV
PLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPYYWWPNIWTEDYISTSVH
HVLIWIHCFTVYLVPCSIFFILNSIIVYKLRRKSNFRLRGYSTGKTTAILFTITSIFATL
WAPRIIMILYHLYGAPIQNRWLVHIMSDIANMLALLNTAINFFLYCFISKRFRTMAAATL
KAFFKCQKQPVQFYTNHNFSITSSPWISPANSHCIKMLVYQYDKNGKPIKVSP
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q6ECI4
Ensemble ID
ENST00000330619.13
HGNC ID
HGNC:22220

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.T616S .
HT115 SNV: p.D205Y; p.E234D; p.E281K; p.A320S .
IGROV1 Deletion: p.W100GfsTer13 .
KMCH1 SNV: p.C682Ter .
KYSE150 SNV: p.G11E .
MCC13 SNV: p.A489T .
MOLT4 SNV: p.K216E; p.R613I .
NCIH3122 SNV: p.V101A .
OPM2 SNV: p.P452S .
RKO SNV: p.V180A .
SH4 SNV: p.L636F .
SHP77 SNV: p.K103N .
UMUC3 SNV: p.Q556H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
N1
 Probe Info  		N.A.  LDD0245  [1]

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.