Details of the Target

General Information of Target

Target ID LDTP15062
Target Name Olfactomedin-like protein 2B (OLFML2B)
Gene Name OLFML2B
Gene ID 25903
Synonyms
Olfactomedin-like protein 2B; Photomedin-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAALPPRPLLLLPLVLLLSGRPTRADSKVFGDLDQVRMTSEGSDCRCKCIMRPLSKDA
CSRVRSGRARVEDFYTVETVSSGTDCRCSCTAPPSSLNPCENEWKMEKLKKQAPELLKLQ
SMVDLLEGTLYSMDLMKVHAYVHKVASQMNTLEESIKANLSRENEVVKDSVRHLSEQLRH
YENHSAIMLGIKKELSRLGLQLLQKDAAAAPATPATGTGSKAQDTARGKGKDISKYGSVQ
KSFADRGLPKPPKEKLLQVEKLRKESGKGSFLQPTAKPRALAQQQAVIRGFTYYKAGKQE
VTEAVADNTLQGTSWLEQLPPKVEGRSNSAEPNSAEQDEAEPRSSERVDLASGTPTSIPA
TTTTATTTPTPTTSLLPTEPPSGPEVSSQGREASCEGTLRAVDPPVRHHSYGRHEGAWMK
DPAARDDRIYVTNYYYGNSLVEFRNLENFKQGRWSNMYKLPYNWIGTGHVVYQGAFYYNR
AFTKNIIKYDLRQRFVASWALLPDVVYEDTTPWKWRGHSDIDFAVDESGLWVIYPAVDDR
DEAQPEVIVLSRLDPGDLSVHRETTWKTRLRRNSYGNCFLVCGILYAVDTYNQQEGQVAY
AFDTHTGTDARPQLPFLNEHAYTTQIDYNPKERVLYAWDNGHQLTYTLHFVV
Target Bioclass
Other
Subcellular location
Secreted
Uniprot ID
Q68BL8
Ensemble ID
ENST00000294794.8
HGNC ID
HGNC:24558

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL72 SNV: p.R203P .
CHL1 SNV: p.G471E .
HCC15 SNV: p.R579S .
HCT15 SNV: p.T380N .
Ishikawa (Heraklio) 02 ER SNV: p.Y561H .
JURKAT SNV: p.Q396Ter .
NCIH2286 SNV: p.W553Ter .
NCIH358 SNV: p.A735V .
PF382 SNV: p.A96T .
RKO SNV: p.T420A .
SKMEL3 SNV: p.R552C .
SKMEL30 SNV: p.K464Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C79(2.25)  LDD3401  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 RD C79(2.43)  LDD2567  [1]
 LDCM0023  KB03 RD C79(3.30)  LDD2984  [1]
 LDCM0024  KB05 RD C79(2.25)  LDD3401  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840