General Information of Target

Target ID LDTP15061
Target Name Olfactomedin-like protein 2A (OLFML2A)
Gene Name OLFML2A
Gene ID 169611
Synonyms
Olfactomedin-like protein 2A; Photomedin-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGAGGGGCPAGGNDFQWCFSQVKGAIDEDVAEADIISTVEFNYSGDLLATGDKGGRVVI
FQREQENKSRPHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAHFLLST
NDKTIKLWKISERDKRAEGYNLKDEDGRLRDPFRITALRVPILKPMDLMVEASPRRIFAN
AHTYHINSISVNSDHETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEF
HPHQCNVFVYSSSKGTIRLCDMRSSALCDRHSKFFEEPEDPSSRSFFSEIISSISDVKFS
HSGRYMMTRDYLSVKVWDLNMESRPVETHQVHEYLRSKLCSLYENDCIFDKFECCWNGSD
SAIMTGSYNNFFRMFDRDTRRDVTLEASRESSKPRASLKPRKVCTGGKRRKDEISVDSLD
FNKKILHTAWHPVDNVIAVAATNNLYIFQDKIN
Target Bioclass
Other
Subcellular location
Secreted
Uniprot ID
Q68BL7
Ensemble ID
ENST00000288815.5
HGNC ID
HGNC:27270

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL120 SNV: p.D28H .
EFO27 SNV: p.G468C DBIA    Probe Info 
HCT15 SNV: p.E43D .
MOLT4 SNV: p.A637T .
MONOMAC6 SNV: p.S57R .
NCIN87 SNV: p.R289W .
SUPT1 SNV: p.A5T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info 
K168(1.12)  LDD3494  [1]
DBIA
 Probe Info 
C8(0.85)  LDD3314  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A101D C395(2.70); C8(1.89)  LDD2250  [2]
 LDCM0023  KB03 A101D C395(2.20); C8(2.75)  LDD2667  [2]
 LDCM0024  KB05 IGR37 C8(0.85)  LDD3314  [2]

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840