General Information of Target

Target ID LDTP15049
Target Name Serine/threonine/tyrosine-interacting-like protein 2 (STYXL2)
Gene Name STYXL2
Gene ID 92235
Synonyms
DUSP27; Serine/threonine/tyrosine-interacting-like protein 2; Inactive dual specificity phosphatase 27
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MERSQCGSRDRGVSGRPHLAPGLVVAAPPPPSPALPVPSGMQVPPAFLRPPSLFLRAAAA
AAAAAAATSGSGGCPPAPGLESGVGAVGCGYPRTPKCARCRNHGVVSALKGHKRFCRWRD
CACAKCTLIAERQRVMAAQVALRRQQAQEESEARGLQRLLCSGLSWPPGGRASGGGGRAE
NPQSTGGPAAGAALGLGALRQASGSATPAFEVFQQDYPEEKQEQKESKCESCQNGQEELI
SKSHQLYLGSSSRSNGVIGKQSIGSSISEYSNKPDSILSPHPGEQSGGEESPRSLSSSDL
ESGNESEWVKDLTATKASLPTVSSRPRDPLDILTKIFPNYRRSRLEGILRFCKGDVVQAI
EQVLNGKEHKPDNRNLANSEELENTAFQRASSFSLAGIGFGTLGNKSAFSPLQTTSASYG
GDSSLYGVNPRVGISPLRLAYSSAGRGLSGFMSPYLTPGLVPTLPFRPALDYAFSGMIRD
SSYLSSKDSITCGRLYFRPNQDNP
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
Subcellular location
Cytoplasm, myofibril, sarcomere
Function May be required for myofiber maturation.
Uniprot ID
Q5VZP5
Ensemble ID
ENST00000271385.9
HGNC ID
HGNC:25034

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C534(3.24)  LDD3440  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 ICC108 C534(1.46)  LDD2381  [1]
 LDCM0023  KB03 ICC108 C534(1.42)  LDD2798  [1]
 LDCM0024  KB05 SNU-245 C534(3.24)  LDD3440  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840