Details of the Target

General Information of Target

Target ID LDTP15038
Target Name Attractin-like protein 1 (ATRNL1)
Gene Name ATRNL1
Gene ID 26033
Synonyms
KIAA0534; Attractin-like protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLCSPTHSAEMSLFLQGPEEMLPLSSEGSEMGSEKEQSPEPHLPEEGEGGKPWRVDDSE
GSWIPPGEKEHGQESLSDELQETHPKKPWQKVTVRARELGDPIAHPRHEADEKPFICAQC
GKTFNNTSNLRTHQRIHTGEKPYKCSECGKSFSRSSNRIRHERIHLEEKHYKCPKCQESF
RRRSDLTTHQQDHLGKRPYRCDICGKSFSQSATLAVHHRTHLEPAPYICCECGKSFSNSS
SFGVHHRTHTGERPYECTECGRTFSDISNFGAHQRTHRGEKPYRCTVCGKHFSRSSNLIR
HQKTHLGEQAGKDSS
Target Bioclass
Other
Subcellular location
Membrane
Function May play a role in melanocortin signaling pathways that regulate energy homeostasis.
Uniprot ID
Q5VV63
Ensemble ID
ENST00000355044.8
HGNC ID
HGNC:29063

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.W386Ter .
A3KAW SNV: p.F1279C .
AN3CA SNV: p.V871A .
HCC1187 SNV: p.N861T .
HCC1395 SNV: p.G531E .
HEC1 SNV: p.L44R .
HLF SNV: p.C748S .
HT Deletion: p.P1336LfsTer12
SNV: p.Y409H		 .
HT1376 SNV: p.W810Ter .
KMS12BM SNV: p.S1351Ter .
LS513 SNV: p.T1362A .
MDAMB453 SNV: p.H484R .
MDST8 SNV: p.E824K .
MEWO SNV: p.F388L; p.P1012L; p.P1101S .
OCILY3 SNV: p.K801N .
UMUC3 Insertion: p.V1235CfsTer49 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		N.A.  LDD2223  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264