Details of the Target

General Information of Target

Target ID LDTP15030
Target Name Dynein axonemal intermediate chain 4 (DNAI4)
Gene Name DNAI4
Gene ID 79819
Synonyms
WDR78; Dynein axonemal intermediate chain 4; WD repeat-containing protein 78
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVL
DKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGV
GEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKK
IGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTR
PTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALS
EALPGDNVGFKVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPV
LDCHMAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPP
LGRFAVRDMRQTVAVGVIKAVDKKAAGAGKVTKSAQKAQKAK
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, flagellum axoneme
Function Plays a critical role in the assembly of axonemal dynein complex, thereby playing a role in ciliary motility.
Uniprot ID
Q5VTH9
Ensemble ID
ENST00000371023.7
HGNC ID
HGNC:26252

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.L135R .
HCC1395 SNV: p.G626R .
HT115 SNV: p.G314S .
LNCaP clone FGC Deletion: p.I226LfsTer2
SNV: p.D215Y		 .
MEWO SNV: p.D392G .
MIAPACA2 SNV: p.S489R .
NCIH1793 SNV: p.T293I .
REC1 SNV: p.K794R .
SHP77 SNV: p.E413K .
T98G SNV: p.L350I .
TFK1 SNV: p.S147Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0167  [1]

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060