Details of the Target

General Information of Target

Target ID LDTP15015
Target Name Sodium/hydrogen exchanger 11 (SLC9C2)
Gene Name SLC9C2
Gene ID 284525
Synonyms
SLC9A11; Sodium/hydrogen exchanger 11; Na(+)/H(+) exchanger 11; NHE-11; Solute carrier family 9 member 11; Solute carrier family 9 member C2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAPSPGPREVLAPSPEAGCRAVTSSRRGLLWRLRDKQSRLGLFEISPGHELHGMTCMMQ
AGLWAATQVSMDHPPTGPPSRDDFSEVLTQVHEGFELGTLAGPAFAWLRRSLGLAEEDYQ
AALGPGGPYLQFLSTSKSKASFFLSHDQRFFLKTQGRREVQALLAHLPRYVQHLQRHPHS
LLARLLGVHSLRVDRGKKTYFIVMQSVFYPAGRISERYDIKGCEVSRWVDPAPEGSPLVL
VLKDLNFQGKTINLGPQRSWFLRQMELDTTFLRELNVLDYSLLIAFQRLHEDERGPGSSL
IFRTARSVQGAQSPEESRAQNRRLLPDAPNALHILDGPEQRYFLGVVDLATVYGLRKRLE
HLWKTLRYPGRTFSTVSPARYARRLCQWVEAHTE
Target Bioclass
Transporter and channel
Family
Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
Subcellular location
Membrane
Function Involved in pH regulation.
Uniprot ID
Q5TAH2
Ensemble ID
ENST00000367714.4
HGNC ID
HGNC:28664

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0233  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0233  [1]

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.