General Information of Target

Target ID LDTP14995
Target Name DNL-type zinc finger protein (DNLZ)
Gene Name DNLZ
Gene ID 728489
Synonyms
C9orf151; DNL-type zinc finger protein; Hsp70-escort protein 1; HEP1; mtHsp70-escort protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTVLEITLAVILTLLGLAILAILLTRWARCKQSEMYISRYSSEQSARLLDYEDGRGSRHA
YSTQSDTSYDNRERSKRDYTPSTNSLVSMASKFSLGQTELILLLMCFILALSRSSIGSIK
CLQTTEEPPSRTAGAMMQFTAPIPGATGPIKLSQKTIVQTPGPIVQYPGSNAGPPSAPRG
PPMAPIIISQRTARIPQVHTMDSSGKITLTPVVILTGYMDEELAKKSCSKIQILKCGGTA
RSQNSREENKEALKNDIIFTNSVESLKSAHIKEPEREGKGTDLEKDKIGMEVKVDSDAGI
PKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVV
LKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKV
PKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGV
LKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEING
EKSKGSKRAKANTGRKYNKKVEE
Target Bioclass
Other
Subcellular location
Mitochondrion
Function May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation.
Uniprot ID
Q5SXM8
Ensemble ID
ENST00000371738.4
HGNC ID
HGNC:33879

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C75(1.32)  LDD3365  [1]
NAIA_5
 Probe Info 
N.A.  LDD2223  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2780 C75(1.24)  LDD2254  [1]
 LDCM0023  KB03 A101D C75(1.29)  LDD2667  [1]
 LDCM0024  KB05 OVCAR-3 C75(1.32)  LDD3365  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264