Details of the Target

General Information of Target

Target ID LDTP14986
Target Name NKAP-like protein (NKAPL)
Gene Name NKAPL
Gene ID 222698
Synonyms
C6orf194; NKAP-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCSTMSAPTCLAHLPPCFLLLALVLVPSDASGQSSRNDWQVLQPEGPMLVAEGETLLLRC
MVVGSCTDGMIKWVKVSTQDQQEIYNFKRGSFPGVMPMIQRTSEPLNCDYSIYIHNVTRE
HTGTYHCVRFDGLSEHSEMKSDEGTSVLVKGAGDPEPDLWIIQPQELVLGTTGDTVFLNC
TVLGDGPPGPIRWFQGAGLSREAIYNFGGISHPKETAVQASNNDFSILLQNVSSEDAGTY
YCVKFQRKPNRQYLSGQGTSLKVKAKSTSSKEAEFTSEPATEMSPTGLLVVFAPVVLGLK
AITLAALLLALATSRRSPGQEDVKTTGPAGAMNTLAWSKGQE
Target Bioclass
Other
Family
NKAP family
Subcellular location
Nucleus
Function Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis.
Uniprot ID
Q5M9Q1
Ensemble ID
ENST00000343684.4
HGNC ID
HGNC:21584

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y361(25.00)  LDD3495  [1]
DBIA
 Probe Info  		C336(0.76)  LDD1571  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0367  CL1 HEK-293T C336(0.76)  LDD1571  [2]
 LDCM0370  CL101 HEK-293T C336(0.89)  LDD1574  [2]
 LDCM0374  CL105 HEK-293T C336(1.02)  LDD1578  [2]
 LDCM0378  CL109 HEK-293T C336(1.60)  LDD1582  [2]
 LDCM0383  CL113 HEK-293T C336(0.85)  LDD1587  [2]
 LDCM0387  CL117 HEK-293T C336(0.83)  LDD1591  [2]
 LDCM0392  CL121 HEK-293T C336(0.82)  LDD1596  [2]
 LDCM0396  CL125 HEK-293T C336(0.69)  LDD1600  [2]
 LDCM0400  CL13 HEK-293T C336(0.98)  LDD1604  [2]
 LDCM0413  CL25 HEK-293T C336(1.09)  LDD1617  [2]
 LDCM0426  CL37 HEK-293T C336(0.83)  LDD1630  [2]
 LDCM0439  CL49 HEK-293T C336(0.75)  LDD1643  [2]
 LDCM0453  CL61 HEK-293T C336(0.96)  LDD1656  [2]
 LDCM0466  CL73 HEK-293T C336(0.85)  LDD1669  [2]
 LDCM0479  CL85 HEK-293T C336(0.93)  LDD1682  [2]
 LDCM0492  CL97 HEK-293T C336(0.80)  LDD1695  [2]

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402