Details of the Target

General Information of Target

Target ID LDTP14972
Target Name Probable ribonuclease ZC3H12B (ZC3H12B)
Gene Name ZC3H12B
Gene ID 340554
Synonyms
CXorf32; MCPIP2; Probable ribonuclease ZC3H12B; EC 3.1.-.-; MCP-induced protein 2; Zinc finger CCCH domain-containing protein 12B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFKRHKSLASERKRALLSQRATRFILKDDMRNFHFLSKLVLSAGPLRPTPAVKHSKTTHF
EIEIFDAQTRKQICILDKVTQSSTIHDVKQKFHKACPKWYPSRVGLQLECGGPFLKDYIT
IQSIAASSIVTLYATDLGQQVSWTTVFLAEYTGPLLIYLLFYLRIPCIYDGKESARRLRH
PVVHLACFCHCIHYIRYLLETLFVHKVSAGHTPLKNLIMSCAFYWGFTSWIAYYINHPLY
TPPSFGNRQITVSAINFLICEAGNHFINVMLSHPNHTGNNACFPSPNYNPFTWMFFLVSC
PNYTYEIGSWISFTVMTQTLPVGIFTLLMSIQMSLWAQKKHKIYLRKFNSYIHRKSAMIP
FIL
Target Bioclass
Enzyme
Family
ZC3H12 family
Function May function as RNase and regulate the levels of target RNA species.
Uniprot ID
Q5HYM0
Ensemble ID
ENST00000338957.5
HGNC ID
HGNC:17407

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.Q93Ter .
HCT15 SNV: p.Q691H .
JHH6 SNV: p.V277F .
L428 Insertion: p.E379GfsTer12 .
MCC13 SNV: p.Y530Ter .
MELJUSO SNV: p.S50R .
NALM6 SNV: p.R572Q .
NCIH1666 SNV: p.P651T .
NCIH2291 SNV: p.V570A .
NUGC3 SNV: p.Y534C .
SNGM SNV: p.T249I; p.R762Q .
SNU1 SNV: p.A143V .
TC71 SNV: p.S53T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C334(1.82)  LDD3372  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A3-KAW C334(3.11)  LDD2257  [1]
 LDCM0023  KB03 A3-KAW C334(6.19)  LDD2674  [1]
 LDCM0024  KB05 OCI-Ly3 C334(1.82)  LDD3372  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840