Details of the Target

General Information of Target

Target ID LDTP14934
Target Name Alanine and arginine-rich domain-containing protein (AARD)
Gene Name AARD
Gene ID 441376
Synonyms
C8orf85; Alanine and arginine-rich domain-containing protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEAARPFAREWRAQSLPLAVGGVLKLRLCELWLLLLGSSLNARFLPDEEDVDFINEYVNL
HNELRGDVIPRGSNLRFMTWDVALSRTARAWGKKCLFTHNIYLQDVQMVHPKFYGIGENM
WVGPENEFTASIAIRSWHAEKKMYNFENGSCSGDCSNYIQLVWDHSYKVGCAVTPCSKIG
HIIHAAIFICNYAPGGTLTRRPYEPGIFCTRCGRRDKCTDFLCSNADRDQATYYRFWYPK
WEMPRPVVCDPLCTFILLLRILCFILCVITVLIVQSQFPNILLEQQMIFTPEESEAGNEE
EEKEEEKKEKEEMEMEIMEMEEEKEEREEEEEETQKEKMEEEEK
Target Bioclass
Other
Uniprot ID
Q4LEZ3
Ensemble ID
ENST00000378279.4
HGNC ID
HGNC:33842

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY-1
 Probe Info  		R65(0.00); R73(0.00); R77(0.00)  LDD0246  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntaxin-1A (STX1A) Syntaxin family Q16623
Syntaxin-5 (STX5) Syntaxin family Q13190
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centromere protein Q (CENPQ) CENP-Q/OKP1 family Q7L2Z9
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
Keratin, type I cytoskeletal 24 (KRT24) Intermediate filament family Q2M2I5
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Vacuolar protein sorting-associated protein 37C (VPS37C) VPS37 family A5D8V6
GRIP1-associated protein 1 (GRIPAP1) . Q4V328
LIM domain transcription factor LMO4 (LMO4) . P61968
Melanoma-associated antigen B4 (MAGEB4) . O15481
Protein moonraker (KIAA0753) . Q2KHM9

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.