Details of the Target

General Information of Target

Target ID LDTP14925
Target Name LON peptidase N-terminal domain and RING finger protein 3 (LONRF3)
Gene Name LONRF3
Gene ID 79836
Synonyms
RNF127; LON peptidase N-terminal domain and RING finger protein 3; RING finger protein 127
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSLLGRDYNSELNSLDNGPQSPSESSSSITSENVHPAGEAGLSMMQTLIHLLKCNIGTGL
LGLPLAIKNAGLLVGPVSLLAIGVLTVHCMVILLNCAQHLSQRLQKTFVNYGEATMYGLE
TCPNTWLRAHAVWGRYTVSFLLVITQLGFCSVYFMFMADNLQQMVEKAHVTSNICQPREI
LTLTPILDIRFYMLIILPFLILLVFIQNLKVLSVFSTLANITTLGSMALIFEYIMEGIPY
PSNLPLMANWKTFLLFFGTAIFTFEGVGMVLPLKNQMKHPQQFSFVLYLGMSIVIILYIL
LGTLGYMKFGSDTQASITLNLPNCWLYQSVKLMYSIGIFFTYALQFHVPAEIIIPFAISQ
VSESWALFVDLSVRSALVCLTCVSAILIPRLDLVISLVGSVSSSALALIIPALLEIVIFY
SEDMSCVTIAKDIMISIVGLLGCIFGTYQALYELPQPISHSMANSTGVHA
Target Bioclass
Enzyme
Uniprot ID
Q496Y0
Ensemble ID
ENST00000304778.11
HGNC ID
HGNC:21152

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8505C SNV: p.A143G .
CCK81 SNV: p.Q218P .
COLO679 SNV: p.E333K .
HCT15 SNV: p.D442V .
JURKAT SNV: p.E105A .
JVM3 SNV: p.Q58H .
KP4 SNV: p.R80Q .
MCC13 SNV: p.E333K .
MEWO SNV: p.P699L .
RL952 Deletion: p.N520MfsTer2 .
SKMEL24 SNV: p.L473I .
SNGM Substitution: p.A14V .
TE10 Deletion: p.G250_E260del .
TOV21G SNV: p.P37T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0165  [1]
IPM
 Probe Info  		C511(0.00); C424(0.00)  LDD2156  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prohibitin 1 (PHB1) Prohibitin family P35232
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cancer/testis antigen 1 (CTAG1A; CTAG1B) CTAG/PCC1 family P78358
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Desmin (DES) Intermediate filament family P17661
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Amyloid protein-binding protein 2 (APPBP2) . Q92624

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019