Details of the Target
General Information of Target
| Target ID | LDTP14918 | |||||
|---|---|---|---|---|---|---|
| Target Name | UDP-glucuronosyltransferase 3A2 (UGT3A2) | |||||
| Gene Name | UGT3A2 | |||||
| Gene ID | 167127 | |||||
| Synonyms |
UDP-glucuronosyltransferase 3A2; UDPGT 3A2; EC 2.4.1.17 |
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| 3D Structure | ||||||
| Sequence |
MAAAALRAPTQVTVSPETHMDLTKGCVTFEDIAIYFSQDEWGLLDEAQRLLYLEVMLENF
ALVASLGCGHGTEDEETPSDQNVSVGVSQSKAGSSTQKTQSCEMCVPVLKDILHLADLPG QKPYLVGECTNHHQHQKHHSAKKSLKRDMDRASYVKCCLFCMSLKPFRKWEVGKDLPAML RLLRSLVFPGGKKPGTITECGEDIRSQKSHYKSGECGKASRHKHTPVYHPRVYTGKKLYE CSKCGKAFRGKYSLVQHQRVHTGERPWECNECGKFFSQTSHLNDHRRIHTGERPYECSEC GKLFRQNSSLVDHQKIHTGARPYECSQCGKSFSQKATLVKHQRVHTGERPYKCGECGNSF SQSAILNQHRRIHTGAKPYECGQCGKSFSQKATLIKHQRVHTGERPYKCGDCGKSFSQSS ILIQHRRIHTGARPYECGQCGKSFSQKSGLIQHQVVHTGERPYECNKCGNSFSQCSSLIH HQKCHNT |
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| Target Bioclass |
Enzyme
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| Family |
UDP-glycosyltransferase family
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| Subcellular location |
Membrane
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| Function |
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C307(2.21) | LDD3423 | [1] | |
Competitor(s) Related to This Target