Details of the Target

General Information of Target

Target ID LDTP14890
Target Name Transmembrane protein 44 (TMEM44)
Gene Name TMEM44
Gene ID 93109
Synonyms
Transmembrane protein 44
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAPPALQIREANAHLAAVHRRAAELEARLDAAERTVHAQAERLALHDQQLRAALDELGR
AKDREIATLQEQLMTSEATVHSLQATVHQRDELIRQLQPRAELLQDICRRRPPLAGLLDA
LAEAERLGPLPASDPGHPPPGGPGPPLDNSTGEEADRDHLQPAVFGTTV
Target Bioclass
Transporter and channel
Subcellular location
Membrane
Uniprot ID
Q2T9K0
Ensemble ID
ENST00000347147.9
HGNC ID
HGNC:25120

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C342(3.96)  LDD3389  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C389(0.91)  LDD1507  [2]
 LDCM0276  AC17 HEK-293T C389(0.71)  LDD1515  [2]
 LDCM0285  AC25 HEK-293T C389(0.97)  LDD1524  [2]
 LDCM0294  AC33 HEK-293T C389(0.79)  LDD1533  [2]
 LDCM0303  AC41 HEK-293T C389(0.91)  LDD1542  [2]
 LDCM0311  AC49 HEK-293T C389(1.30)  LDD1550  [2]
 LDCM0320  AC57 HEK-293T C389(0.82)  LDD1559  [2]
 LDCM0356  AKOS034007680 HEK-293T C389(0.77)  LDD1570  [2]
 LDCM0404  CL17 HEK-293T C389(0.90)  LDD1608  [2]
 LDCM0417  CL29 HEK-293T C389(0.66)  LDD1621  [2]
 LDCM0431  CL41 HEK-293T C389(0.73)  LDD1635  [2]
 LDCM0440  CL5 HEK-293T C389(1.05)  LDD1644  [2]
 LDCM0444  CL53 HEK-293T C389(1.10)  LDD1647  [2]
 LDCM0457  CL65 HEK-293T C389(1.18)  LDD1660  [2]
 LDCM0470  CL77 HEK-293T C389(1.33)  LDD1673  [2]
 LDCM0483  CL89 HEK-293T C389(0.86)  LDD1686  [2]
 LDCM0022  KB02 ICC19 C342(1.81)  LDD2386  [1]
 LDCM0023  KB03 ICC19 C342(2.03)  LDD2803  [1]
 LDCM0024  KB05 OZ C342(3.96)  LDD3389  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402