Details of the Target

General Information of Target

Target ID LDTP14883
Target Name Probable maltase-glucoamylase 2 (MGAM2)
Gene Name MGAM2
Gene ID 93432
Synonyms
Probable maltase-glucoamylase 2; Maltase-glucoamylase; alpha-glucosidase) pseudogene) [Includes: Glucoamylase; EC 3.2.1.3; Glucan 1,4-alpha-glucosidase)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCAEVGPALCRGMERNSLGCCEAPKKLSLSFSIEAILKRPARRSDMDRPEGPGEEGPGEA
AASGSGLEKPPKDQPQEGRKSKRRVRTTFTTEQLHELEKIFHFTHYPDVHIRSQLAARIN
LPEARVQIWFQNQRAKWRKQEKIGNLGAPQQLSEASVALPTNLDVAGPTWTSTALRRLAP
PTSCCPSAQDQLASAWFPAWITLLPAHPWETQPVPGLPIHQTCIPVLCILPPPHPKWGSI
CATST
Target Bioclass
Enzyme
Family
Glycosyl hydrolase 31 family
Subcellular location
Membrane
Uniprot ID
Q2M2H8
Ensemble ID
ENST00000477922.4
HGNC ID
HGNC:28101
ChEMBL ID
CHEMBL3833502

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.L891F .
AN3CA SNV: p.I13F .
COLO678 SNV: p.N663T .
CORL88 Deletion: p.G2288AfsTer2 .
HCC15 SNV: p.E936Q .
HCT116 SNV: p.A699T; p.S1255N .
HCT15 SNV: p.V814A; p.M2289V .
HEC1B SNV: p.F1501V .
HLF SNV: p.R747K .
HT115 SNV: p.A1225S .
ICC12 Deletion: p.G526AfsTer20 .
IGR1 SNV: p.G440E; p.S1321F .
IM95 Deletion: p.L1174WfsTer8
SNV: p.T1996A		 .
J82 SNV: p.P1938T .
KMCH1 SNV: p.G566R .
KNS42 SNV: p.V2463L .
KYM1 SNV: p.A1358G; p.D1516G .
KYSE30 SNV: p.N1798S; p.H2383Q .
KYSE410 SNV: p.H2383Q .
LN229 SNV: p.I1493V .
MCC13 SNV: p.E1092K .
MDST8 SNV: p.D890N; p.D2420N .
MEWO SNV: p.G1385E; p.G1642R .
MFE319 SNV: p.G431W; p.P1034S; p.Q1685P; p.G1810C .
MM1S Substitution: p.P1429A .
NCIH1793 SNV: p.S882Y .
NCIH2286 SNV: p.Q1226H; p.V1758L .
OPM2 SNV: p.L337P; p.T1941I .
SH4 SNV: p.D1879N .
SHP77 Deletion: .
SNV: p.W331Ter		 .
SHSY5Y Substitution: p.A267S .
SKMEL2 SNV: p.L25F; p.K1055I; p.L1654M .
SKMEL24 SNV: p.P2515S .
SKNSH Substitution: p.A267S .
SNU869 SNV: p.M1418I DBIA    Probe Info 
SUPT1 SNV: p.G1489W .
SW1271 SNV: p.L593I; p.C1390Ter .
TCCSUP SNV: p.E1701K .
TE4 SNV: p.C608Y .
UMUC3 SNV: p.A1848E .
YSCCC SNV: p.S1413I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1390(2.32)  LDD3380  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0020  ARS-1620 HCC44 C65(1.13)  LDD2171  [2]
 LDCM0022  KB02 A101D C1390(1.68)  LDD2250  [1]
 LDCM0023  KB03 COLO-679 C1390(2.04)  LDD2722  [1]
 LDCM0024  KB05 OV-90 C1390(2.32)  LDD3380  [1]
 LDCM0021  THZ1 HCT 116 C65(1.13)  LDD2173  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.