Details of the Target

General Information of Target

Target ID LDTP14877
Target Name Lymphocyte antigen 6K (LY6K)
Gene Name LY6K
Gene ID 54742
Synonyms
CO16; Lymphocyte antigen 6K; Ly-6K
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEAVKAEAWEGAAVAQDLLALGYGGVPGAASRGASCPDFRGLCVRLAAELATLGALEQQR
EAGAEVLSAGDGPGAEEDFLRQLGSLLRELHCPDRALCGGDGAAALREPGAGLRLLRFLC
SELQATRLLCLRSLLDPSPRPPLGEGVVEGAGMVQELDLTLQALGLPRPAPGTPASQLLQ
ELHAKISELQPSLPPGSLQPLLSCSLDAPRWEALESLSQSLRDQYRCRRCLLLKRLDLTT
SAFHWSDRAEAQGEAMRAVLIPIREVLTPESDISIAHVLAARADLSCLVPATSVAVRRGT
CCAINKVLMGNVPDRGGRPNELEPPMPTWRSRREDGGPQCWGRKKKKKK
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Secreted
Function Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. May play a role in cell growth.
TTD ID
T57843
Uniprot ID
Q17RY6
DrugMap ID
TT5GKHN
Ensemble ID
ENST00000292430.10
HGNC ID
HGNC:24225

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EGI1 Deletion: p.C116del .
HGC27 SNV: p.L152P .
IGROV1 SNV: p.V9A .
LN18 SNV: p.C67G .
LNCaP clone FGC SNV: p.F75L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C43(1.43); C46(1.43); C85(1.19); C89(1.19)  LDD0078  [1]
IPM
 Probe Info  		N.A.  LDD0147  [2]
TFBX
 Probe Info  		N.A.  LDD0148  [2]
Acrolein
 Probe Info  		N.A.  LDD0217  [3]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [3]
Methacrolein
 Probe Info  		C54(0.00); C46(0.00)  LDD0218  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0020  ARS-1620 HCC44 C43(1.43); C46(1.43); C85(1.19); C89(1.19)  LDD0078  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0022  KB02 CAL-33 C54(2.06)  LDD2287  [4]
 LDCM0023  KB03 CAL-33 C54(3.15)  LDD2704  [4]
 LDCM0024  KB05 HMCB C54(1.72)  LDD3312  [4]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840