General Information of Target

Target ID LDTP14864
Target Name U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (ZRSR2P1)
Gene Name ZRSR2P1
Synonyms
U2AF1-RS1; U2AF1L1; U2AF1P; U2AF1RS1; U2AFBPL; ZRSR1; U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1; CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1; U2(RNU2) small nuclear RNA auxiliary factor 1-like 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPKRKSPENTEGKDGSKVTKQEPTRRSARLSAKPAPPKPEPKPRKTSAKKEPGAKISRGA
KGKKEEKQEAGKEGTAPSENGETKAEEAQKTESVDNEGE
Target Bioclass
Other
Subcellular location
Nucleus
Uniprot ID
Q15695
HGNC ID
HGNC:12456

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C331(1.99)  LDD3310  [1]
BTD
 Probe Info 
C265(2.50)  LDD2144  [2]
IPM
 Probe Info 
C177(1.39)  LDD1702  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C177(1.39)  LDD1702  [2]
 LDCM0022  KB02 42-MG-BA C331(1.62)  LDD2244  [1]
 LDCM0023  KB03 769-P C331(2.94); C265(3.10)  LDD2663  [1]
 LDCM0024  KB05 COLO792 C331(1.99)  LDD3310  [1]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C265(2.50)  LDD2144  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761