Details of the Target
General Information of Target
| Target ID | LDTP14847 | |||||
|---|---|---|---|---|---|---|
| Target Name | Early placenta insulin-like peptide (INSL4) | |||||
| Gene Name | INSL4 | |||||
| Gene ID | 3641 | |||||
| Synonyms |
Early placenta insulin-like peptide; EPIL; Insulin-like peptide 4; Placentin) [Cleaved into: Early placenta insulin-like peptide B chain; Early placenta insulin-like peptide A chain] |
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| 3D Structure | ||||||
| Sequence |
MSSAPRGPPSVAPLPAGIGRSTAKTPGLPGSLEMGPLTFRDVAIEFSLEEWQCLDTSQQN
LYRNVMLDNYRNLVFLGIAVSKPDLITCLEQGKEPCNMKRHAMVAKPPVVCSHFAQDLWP KQGLKDSFQKVILRRYGKYGHENLQLRKGCKSADEHKVHKRGYNGLNQCLTTTQSKIFQC DKYVKVLHKFSNSNIHKKRQTGKKPFKCKECGKSCCILSQLTQHKKTATRVNFYKCKTCG KAFNQFSNLTKHKIIHPEVNPYKCEECGKAFNQSLTLTKHKKIHTEEKPYKCEDCGKVFS VFSVLTKHKIIHTGTKPYNCEECGKGFSIFSTLTKHKIIHTGEKPYKCNECGKAFNWSST LTKHKRIHTGEKPYKCEECGKAFNQSSTLTRHKIVHTGEKPYKCEECGKAFKRSTTLTKH KRIYTKEKPYKCEECGKAFSVFSTLTKHKIIHTGAKPYKCEECGSAFRAFSTLTEHKRVH TGEKPYKCNECGKAFNWSSTLTKHKRIHTGEKPYKCEECGKAFNRSSNLTRHKKIHTGEK PYKPKRCDSAFDNTPNFSRHKRNHMGEKS |
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| Target Bioclass |
Other
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| Family |
Insulin family
|
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| Subcellular location |
Secreted
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| Function | May play an important role in trophoblast development and in the regulation of bone formation. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C6(3.33) | LDD3440 | [1] | |
|
BTD Probe Info |
 |
C31(1.09) | LDD2094 | [2] | |
|
TFBX Probe Info |
 |
N.A. | LDD0148 | [3] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0022 | KB02 | ICC108 | C6(1.70) | LDD2381 | [1] |
| LDCM0023 | KB03 | ICC108 | C6(1.86) | LDD2798 | [1] |
| LDCM0024 | KB05 | SNU-245 | C6(3.33) | LDD3440 | [1] |
| LDCM0509 | N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide | MDA-MB-231 | C31(0.92) | LDD2102 | [2] |
| LDCM0501 | Nucleophilic fragment 13b | MDA-MB-231 | C31(1.09) | LDD2094 | [2] |
| LDCM0505 | Nucleophilic fragment 15b | MDA-MB-231 | C31(1.71) | LDD2098 | [2] |
| LDCM0512 | Nucleophilic fragment 19a | MDA-MB-231 | C31(1.88) | LDD2105 | [2] |
References