Details of the Target

General Information of Target

Target ID LDTP14841
Target Name Myosin-binding protein C, fast-type (MYBPC2)
Gene Name MYBPC2
Gene ID 4606
Synonyms
MYBPCF; Myosin-binding protein C, fast-type; Fast MyBP-C; C-protein, skeletal muscle fast isoform
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPAPSMDCDVSTLVACVVDVEVFTNQEVKEKFEGLFRTYDDCVTFQLFKSFRRVRINFSN
PKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVG
WQPINDATPVLNYDLLYAVAKLGPGEKYELHAGTESTPSVVVHVCDSDIEEEEDPKTSPK
PKIIQTRRPGLPPSVSN
Target Bioclass
Immunoglobulin
Family
Immunoglobulin superfamily, MyBP family
Function
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
Uniprot ID
Q14324
Ensemble ID
ENST00000357701.6
HGNC ID
HGNC:7550

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C335(2.69)  LDD3377  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 OPM-2 C335(1.82)  LDD2543  [1]
 LDCM0023  KB03 DEL C335(1.78)  LDD2732  [1]
 LDCM0024  KB05 OPM-2 C335(2.69)  LDD3377  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840