Details of the Target

General Information of Target

Target ID LDTP14831
Target Name Putative E3 ubiquitin-protein ligase makorin-4 (MKRN4P)
Gene Name MKRN4P
Synonyms
MKRN4; MKRNP5; RNF64; ZNF127L1; Putative E3 ubiquitin-protein ligase makorin-4; EC 2.3.2.27; Makorin RING finger protein pseudogene 4; Makorin RING finger protein pseudogene 5; RING finger protein 64; RING-type E3 ubiquitin transferase makorin-4; Zinc finger protein 127-Xp; ZNF127-Xp; Zinc finger protein 127-like 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNTLQGPVSFKDVAVDFTQEEWRQLDPDEKIAYGDVMLENYSHLVSVGYDYHQAKHHHGV
EVKEVEQGEEPWIMEGEFPCQHSPEPAKAIKPIDRKSVHQICSGPVVLSLSTAVKELVEN
SLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLISFSSETSHM
Target Bioclass
Enzyme
Function May act as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
Uniprot ID
Q13434
HGNC ID
HGNC:7115

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C294(1.38)  LDD3339  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2058 C294(1.29)  LDD2253  [1]
 LDCM0023  KB03 A2058 C294(1.38)  LDD2670  [1]
 LDCM0024  KB05 NALM-6 C294(1.38)  LDD3339  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060