Details of the Target

General Information of Target

Target ID LDTP14829
Target Name Myosin-binding protein H (MYBPH)
Gene Name MYBPH
Gene ID 4608
Synonyms
Myosin-binding protein H; MyBP-H; H-protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MISRMEKMTMMMKILIMFALGMNYWSCSGFPVYDYDPSSLRDALSASVVKVNSQSLSPYL
FRAFRSSLKRVEVLDENNLVMNLEFSIRETTCRKDSGEDPATCAFQRDYYVSTAVCRSTV
KVSAQQVQGVHARCSWSSSTSESYSSEEMIFGDMLGSHKWRNNYLFGLISDESISEQFYD
RSLGIMRRVLPPGNRRYPNHRHRARINTDFE
Target Bioclass
Immunoglobulin
Family
Immunoglobulin superfamily, MyBP family
Function Binds to myosin; probably involved in interaction with thick myofilaments in the A-band.
Uniprot ID
Q13203
Ensemble ID
ENST00000255416.9
HGNC ID
HGNC:7552

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C12(1.03)  LDD3401  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 ICC18 C454(1.60)  LDD2385  [1]
 LDCM0023  KB03 ICC26 C454(1.39)  LDD2807  [1]
 LDCM0024  KB05 RD C12(1.03)  LDD3401  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840