Details of the Target

General Information of Target

Target ID LDTP14820
Target Name Proline-rich nuclear receptor coactivator 1 (PNRC1)
Gene Name PNRC1
Gene ID 10957
Synonyms
PROL2; Proline-rich nuclear receptor coactivator 1; Proline-rich protein 2; Protein B4-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAIGVHLGCTSACVAVYKDGRAGVVANDAGDRVTPAVVAYSENEEIVGLAAKQSRIRNI
SNTVMKVKQILGRSSSDPQAQKYIAESKCLVIEKNGKLRYEIDTGEETKFVNPEDVARLI
FSKMKETAHSVLGSDANDVVITVPFDFGEKQKNALGEAARAAGFNVLRLIHEPSAALLAY
GIGQDSPTGKSNILVFKLGGTSLSLSVMEVNSGIYRVLSTNTDDNIGGAHFTETLAQYLA
SEFQRSFKHDVRGNARAMMKLTNSAEVAKHSLSTLGSANCFLDSLYEGQDFDCNVSRARF
ELLCSPLFNKCIEAIRGLLDQNGFTADDINKVVLCGGSSRIPKLQQLIKDLFPAVELLNS
IPPDEVIPIGAAIEAGILIGKENLLVEDSLMIECSARDILVKGVDESGASRFTVLFPSGT
PLPARRQHTLQAPGSISSVCLELYESDGKNSAKEETKFAQVVLQDLDKKENGLRDILAVL
TMKRDGSLHVTCTDQETGKCEAISIEIAS
Target Bioclass
Other
Family
PNRC family, PNRC1 subfamily
Subcellular location
Nucleus
Function Nuclear receptor coactivator. May play a role in signal transduction.
Uniprot ID
Q12796
Ensemble ID
ENST00000336032.4
HGNC ID
HGNC:17278

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
Ishikawa (Heraklio) 02 ER Deletion: p.Q71SfsTer112 .
NCIH23 SNV: p.L14M .
SKOV3 Deletion: p.Q71SfsTer112 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		N.A.  LDD0273  [1]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270