Details of the Target

General Information of Target

Target ID LDTP14796
Target Name Small EDRK-rich factor 2 (SERF2)
Gene Name SERF2
Gene ID 10169
Synonyms
FAM2C; Small EDRK-rich factor 2; Gastric cancer-related protein VRG107; Protein 4F5-related; 4F5rel; h4F5rel
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVRPYPLIYFLFLPLGACFPLLDRREPTDAMGGLGAGERWADLAMGPRPHSVWGSSRWLR
ASQPQALLVIARGLQTSGREHAGCRFRFGRQDEGSEATGFLPAAGEKTSGPLGNLAEELN
GYSRKKGGFSFRFGRR
Target Bioclass
Other
Family
SERF family
Function
Positive regulator of amyloid protein aggregation and proteotoxicity. Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formation of aggregates.
Uniprot ID
P84101
Ensemble ID
ENST00000249786.9
HGNC ID
HGNC:10757

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ATP probe
 Probe Info  		N.A.  LDD0199  [1]
ATP probe
 Probe Info  		N.A.  LDD0035  [2]
YN-1
 Probe Info  		D40(0.00); E42(0.00)  LDD0447  [3]

References

1 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
2 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.