Details of the Target
General Information of Target
| Target ID | LDTP14756 | |||||
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| Target Name | Endogenous retrovirus group FC1 member 1 Env polyprotein (ERVFC1-1) | |||||
| Gene Name | ERVFC1-1 | |||||
| Synonyms |
Endogenous retrovirus group FC1 member 1 Env polyprotein; Envelope polyprotein; Fc2deltaenv; HERV-F(c)2_7q36.2 provirus ancestral Env polyprotein) [Includes: Surface protein; SU; Truncated transmembrane protein; TM)]
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| 3D Structure | ||||||
| Sequence |
MDPLHTIEKVPARRNIHDRGHQGHRMGDGTPGRPKISVQQMTRFSLIIFFLSAPFVVNAS
TSNVFLQWAHSYADGLQQGDPCWVCGSLPVTNTMELPWWVSPLQGKDWVFFQSFIGDLKQ WTGAQMTGVTRKNISEWPINKTLNEPGHDKPFSVNETRDKVIAFAIPLLDTKVFVQTSRP QNTQYRNGFLQIWDGFIWLTATKGHLSQIAPLCWEQRNHSLDNWPNTTRVMGWIPPGQCR HTILLQQRDLFATDWSQQPGLNWYAPNGTQWLCSPNLWPWLPSGWLGCCTLGIPWAQGRW VKTMEVYPYLPHVVNQGTRAIVHRNDHLPTIFMPSVGLGTVIQHIEALANFTQRALNDSL QSISLMNAEVYYMHEDILQNRMALDILTAAEGGTCALIKTECCVYIPNNSRNISLALEDT CRQIQVISSSALSLHDWIASQFSGRPSWWQKILIVLATLWSVGIALCCGLYFCRMFSQHI PQTHSIIFQQELPLSPPSQEHYQSQRDIFHSNAP |
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| Target Bioclass |
Other
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| Family |
Gamma type-C retroviral envelope protein family, HERV class-I F(c)2 env subfamily
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| Subcellular location |
Virion
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| Function |
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.
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| Uniprot ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C132(0.91) | LDD1492 | [1] | |
Competitor(s) Related to This Target