Details of the Target

General Information of Target

Target ID LDTP14754
Target Name Keratin-associated protein 10-12 (KRTAP10-12)
Gene Name KRTAP10-12
Gene ID 386685
Synonyms
KAP10.12; KAP18-12; KRTAP10.12; KRTAP18-12; KRTAP18.12; Keratin-associated protein 10-12; High sulfur keratin-associated protein 10.12; Keratin-associated protein 10.12; Keratin-associated protein 18-12; Keratin-associated protein 18.12
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATSTMSVCSSAYSDSWQVDACPESCCEPPCCATSCCAPAPCLTLVCTPVSCVSSPCCQA
ACEPSPCQSGCTSSCTPSCCQQSSCQPACCTSSPCQQACCVPVCCKPVCCVPVCCKPVCC
KPICCVPVCSGASSSCCQQSSRQPACCTTSCCRPSSSVSLLCRPVCRSTCCVPIPSCCAP
ASTCQPSCCRPASCVSLLCRPTCSRLSSACCGLSSGQKSSC
Target Bioclass
Other
Family
KRTAP type 10 family
Function
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Uniprot ID
P60413
Ensemble ID
ENST00000400365.3
HGNC ID
HGNC:20533

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C199(6.88)  LDD0315  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0023  KB03 Jurkat C199(6.88)  LDD0315  [1]

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060