Details of the Target | Chem(Pro)²

General Information of Target

Target ID	LDTP14702
Target Name	Arylsulfatase D (ARSD)
Gene Name	ARSD
Gene ID	414
Synonyms	Arylsulfatase D; ASD; EC 3.1.6.-
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MHGRKDDAQKQPVKNQLGLNPQSHLPELQLFQAEGKIYKYDHMEKSVNSSSLVSPPQRIS STVKTHISHTYECNFVDSLFTQKEKANIGTEHYKCSERGKAFHQGLHFTIHQIIHTKETQ FKCDICGKIFNKKSNLASHQRIHTGEKPYKCNECGKVFHNMSHLAQHRRIHTGEKPYKCN ECGKVFNQISHLAQHQRIHTGEKPYKCNECGKVFHQISHLAQHRTIHTGEKPYECNKCGK VFSRNSYLVQHLIIHTGEKPYRCNVCGKVFHHISHLAQHQRIHTGEKPYKCNECGKVFSH KSSLVNHWRIHTGEKPYKCNECGKVFSHKSSLVNHWRIHTGEKPYKCNECGKVFSRNSYL AQHLIIHAGEKPYKCDECDKAFSQNSHLVQHHRIHTGEKPYKCDECGKVFSQNSYLAYHW RIHTGEKAYKCNECGKVFGLNSSLAHHRKIHTGEKPFKCNECGKAFSMRSSLTNHHAIHT GEKHFKCNECGKLFRDNSYLVRHQRFHAGKKSNTCN
Target Bioclass	Enzyme
Family	Sulfatase family
Subcellular location	Lysosome
Uniprot ID	P51689
Ensemble ID	ENST00000381154.6
HGNC ID	HGNC:717

Target Site Mutations in Different Cell Lines

Cell line	Mutation details			Probe for labeling this protein in this cell
HS936T	Substitution: p.G249K			.
L428	SNV: p.R521T			.
MCAS	SNV: p.A38T			.
RKO	SNV: p.D532Y			.
SHSY5Y	SNV: p.G152C			.
SKNSH	SNV: p.G152C			.

Probe(s) Labeling This Target

PAL-AfBPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
STS-1 Probe Info			N.A.	LDD0137	[1]

References

1	Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.