Details of the Target

General Information of Target

Target ID LDTP14681
Target Name Prostaglandin E2 receptor EP2 subtype (PTGER2)
Gene Name PTGER2
Gene ID 5732
Synonyms
Prostaglandin E2 receptor EP2 subtype; PGE receptor EP2 subtype; PGE2 receptor EP2 subtype; Prostanoid EP2 receptor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALEGMSKRKRKRSVQEGENPDDGVRGSPPEDYRLGQVASSLFRGEHHSRGGTGRLASLF
SSLEPQIQPVYVPVPKQTIKKTKRNEEEESTSQIERPLSQEPAKKVKAKKKHTNAEKKLA
DRESALASADLEEEIHQKQGQKRKNSQPGVKVADRKILDDTEDTVVSQRKKIQINQEEER
LKNERTVFVGNLPVTCNKKKLKSFFKEYGQIESVRFRSLIPAEGTLSKKLAAIKRKIHPD
QKNINAYVVFKEESAATQALKRNGAQIADGFRIRVDLASETSSRDKRSVFVGNLPYKVEE
SAIEKHFLDCGSIMAVRIVRDKMTGIGKGFGYVLFENTDSVHLALKLNNSELMGRKLRVM
RSVNKEKFKQQNSNPRLKNVSKPKQGLNFTSKTAEGHPKSLFIGEKAVLLKTKKKGQKKS
GRPKKQRKQK
Target Type
Successful
Target Bioclass
GPCR
Family
G-protein coupled receptor 1 family
Subcellular location
Cell membrane
Function
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.
TTD ID
T38529
Uniprot ID
P43116
DrugMap ID
TT1ZAVI
Ensemble ID
ENST00000245457.6
HGNC ID
HGNC:9594
ChEMBL ID
CHEMBL1881

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C234(12.94)  LDD1705  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0024  KB05 T cell C234(12.94)  LDD1705  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 8 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alprostadil Small molecular drug D0I4DQ
Dinoprostone Small molecular drug D06FEA
Iloprost Small molecular drug D05ZTH
Misoprostol Small molecular drug DB00929
Mycophenolate Mofetil Small molecular drug D04FBR
Treprostinil Small molecular drug DB00374
Gemeprost . DB08964
Omidenepag Isopropyl . DB15071
Phase 4
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Laropiprant Small molecular drug D0WL5V
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
De-117 . D00SOZ
Phase 2
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
16,16-dimethyl-pge2 Small molecular drug D0U7WF
Cp-533536 Small molecular drug D0G6EI
Taprenepag Small molecular drug D0Y3LL
Phase 1
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pf-4418948 Small molecular drug D0S5EF
Tpst-1495 . D54FYW
Clinical trial
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pgf2alpha Small molecular drug D00HTY
Investigative
Click To Hide/Show 26 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
11-deoxy-pge1 Small molecular drug D0G5MT
17-phenyl-omega-trinor-pge2 Small molecular drug D0X2MQ
19(R)-oh-pge2 Small molecular drug D05MXO
3-(2-((E)-3-phenylprop-1-enyl)Phenyl)Acrylic Acid Small molecular drug D0W4GQ
3-(2-(4-methoxycinnamyl)Phenyl)Acrylic Acid Small molecular drug D02SAD
3-(2-(Naphthalen-2-ylmethyl)Phenyl)Acrylic Acid Small molecular drug D0Z3XJ
3-(2-cinnamylphenyl)Acrylic Acid Small molecular drug D02LXJ
Ah13205 Small molecular drug D01IJD
Ah6809 Small molecular drug D0J9PG
Butaprost (Free Acid Form) Small molecular drug D08MNO
Carbacyclin Small molecular drug D0W7RI
Cicaprost Small molecular drug D05SFA
Isocarbacyclin Small molecular drug D02YIJ
M&b 28767 Small molecular drug D0BN1U
Ono-ae-248 Small molecular drug D0CW4T
Ono-ae1-329 Small molecular drug D06VZS
Pf-00212062 Small molecular drug D0YD9E
Pgd2 Small molecular drug D06KBO
Pmid20080612c1 Small molecular drug D0ST1M
Tg4-155 Small molecular drug D03WTU
Tg7-171 Small molecular drug D0NY1J
Trichostatin A Small molecular drug DB04297
U46619 Small molecular drug D03PLH
Limaprost . DB09211
R-65 . D06PVN
Rivenprost . DB16315
Patented
Click To Hide/Show 16 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Butaprost Small molecular drug D0W2OT
Pmid25772215-compound-ep20082149552c9 Small molecular drug D0ZT9N
Pmid25772215-compound-ep2149552diaminopyrimidines Small molecular drug D01JJN
Pmid25772215-compound-us02014179750m1 Small molecular drug D0HJ1O
Pmid25772215-compound-us02014179750m2 Small molecular drug D0A2VQ
Pmid25772215-compound-us02014179750m3 Small molecular drug D0Y8GN
Pmid25772215-compound-us02014179750tg6-10-1 Small molecular drug D0NQ6N
Pmid25772215-compound-us02014179750tg6-129 Small molecular drug D0O2EN
Pmid25772215-compound-us02014179750tg7-112-2 Small molecular drug D0D0PF
Pmid25772215-compound-us02014179750tg7-170 Small molecular drug D01ERV
Pmid25772215-compound-us02014179750tg7-74 Small molecular drug D0H6QG
Pmid25772215-compound-us02014179750tg7-76 Small molecular drug D0RD5O
Pmid25772215-compound-us02014179750tg8-15 Small molecular drug D06ZEI
Pmid25772215-compound-wo2012177618m4 Small molecular drug D03IKW
Pmid25772215-compound-wo2012177618m5 Small molecular drug D0G6UA
Pmid25772215-compound-wo2012177618m6 Small molecular drug D01FIM
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ono-8815ly Small molecular drug D02RUO

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.