Details of the Target

General Information of Target

Target ID LDTP14668
Target Name Cyclin-dependent kinases regulatory subunit 2 (CKS2)
Gene Name CKS2
Gene ID 1164
Synonyms
Cyclin-dependent kinases regulatory subunit 2; CKS-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGA
IVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDS
MICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILY
SESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTV
TMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQ
EMRKTFKEIICCRGFRIACSFPRRD
Target Bioclass
Other
Family
CKS family
Function Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
Uniprot ID
P33552
Ensemble ID
ENST00000314355.7
HGNC ID
HGNC:2000

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K30(5.47); K75(7.14)  LDD0277  [1]
Probe 1
 Probe Info  		Y7(54.99); Y8(21.23); Y12(10,164.08)  LDD3495  [2]
HHS-475
 Probe Info  		Y17(0.92); Y7(2.30)  LDD0264  [3]
5E-2FA
 Probe Info  		N.A.  LDD2235  [4]
ATP probe
 Probe Info  		K4(0.00); K30(0.00); K11(0.00)  LDD0199  [5]
m-APA
 Probe Info  		H3(0.00); H16(0.00)  LDD2231  [4]
1c-yne
 Probe Info  		N.A.  LDD0228  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y17(0.92); Y7(2.30)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y7(0.60); Y17(0.72)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y17(0.92); Y7(2.13)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y7(0.63); Y17(0.90)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y7(0.53); Y17(1.21)  LDD0268  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-dependent kinase 3 (CDK3) CMGC Ser/Thr protein kinase family Q00526

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.