Details of the Target
General Information of Target
| Target ID | LDTP14667 | |||||
|---|---|---|---|---|---|---|
| Target Name | Melanocortin receptor 5 (MC5R) | |||||
| Gene Name | MC5R | |||||
| Gene ID | 4161 | |||||
| Synonyms |
Melanocortin receptor 5; MC5-R; MC-2 |
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| 3D Structure | ||||||
| Sequence |
MGPVIGMTPDKRAETPGAEKIAGLSQIYKMGSLPEAVDAARPKATLVDSESADDELTNLN
WLHESTNLLTNFSLGSEGLPIVSPLYDIEGDDVPSFGPACYQNPEKKSATSKPPYSFSLL IYMAIEHSPNKCLPVKEIYSWILDHFPYFATAPTGWKNSVRHNLSLNKCFQKVERSHGKV NGKGSLWCVDPEYKPNLIQALKKQPFSSASSQNGSLSPHYLSSVIKQNQVRNLKESDIDA AAAMMLLNTSIEQGILECEKPLPLKTALQKKRSYGNAFHHPSAVRLQESDSLATSIDPKE DHNYSASSMAAQRCASRSSVSSLSSVDEVYEFIPKNSHVGSDGSEGFHSEEDTDVDYEDD PLGDSGYASQPCAKISEKGQSGKKMRKQTCQEIDEELKEAAGSLLHLAGIRTCLGSLIST AKTQNQKQRKK |
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| Target Type |
Clinical trial
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| Target Bioclass |
GPCR
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| Family |
G-protein coupled receptor 1 family
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| Subcellular location |
Cell membrane
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| Function |
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.
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| TTD ID | ||||||
| Uniprot ID | ||||||
| DrugMap ID | ||||||
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Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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NAIA_4 Probe Info |
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N.A. | LDD2226 | [1] | |