Details of the Target

General Information of Target

Target ID LDTP14656
Target Name Calretinin (CALB2)
Gene Name CALB2
Gene ID 794
Synonyms
CAB29; Calretinin; CR; 29 kDa calbindin
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSYQQQQCKQPCQPPPVCPTPKCPEPCPPPKCPEPCPSPKCPQPCPPQQCQQKYPPVTPS
PPCQPKCPPKSK
Target Bioclass
Transporter and channel
Family
Calbindin family
Function Calretinin is a calcium-binding protein which is abundant in auditory neurons.
Uniprot ID
P22676
Ensemble ID
ENST00000302628.9
HGNC ID
HGNC:1435

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY-1
 Probe Info  		100.00  LDD0243  [1]
N1
 Probe Info  		100.00  LDD0242  [1]
STPyne
 Probe Info  		K141(10.00); K245(8.53); K255(10.00); K67(4.07)  LDD0277  [2]
m-APA
 Probe Info  		10.76  LDD0403  [3]
DBIA
 Probe Info  		C101(0.74)  LDD3312  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 10.76  LDD0403  [3]
 LDCM0022  KB02 AGS C101(1.02)  LDD2263  [4]
 LDCM0023  KB03 AGS C266(2.17); C101(1.12)  LDD2680  [4]
 LDCM0024  KB05 HMCB C101(0.74)  LDD3312  [4]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Calcium Phosphate Small molecular drug DB11348
Calcium Phosphate Dihydrate Small molecular drug DB14481
Calcium Citrate . DB11093
Calcium Levulinate . DB13800

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060