Details of the Target

General Information of Target

Target ID LDTP14592
Target Name Homeobox protein Hox-C6 (HOXC6)
Gene Name HOXC6
Gene ID 3223
Synonyms
HOX3C; Homeobox protein Hox-C6; Homeobox protein CP25; Homeobox protein HHO.C8; Homeobox protein Hox-3C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALSAEDRALVRALWKKLGSNVGVYTTEALERTFLAFPATKTYFSHLDLSPGSSQVRAHG
QKVADALSLAVERLDDLPHALSALSHLHACQLRVDPASFQLLGHCLLVTLARHYPGDFSP
ALQASLDKFLSHVISALVSEYR
Target Bioclass
Transcription factor
Family
Antp homeobox family
Subcellular location
Nucleus
Function Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Uniprot ID
P09630
Ensemble ID
ENST00000243108.5
HGNC ID
HGNC:5128

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.R170Q .
CAL51 SNV: p.A15T .
HT115 SNV: p.D82Y .
LS180 Insertion: p.L154PfsTer48 .
MCC26 SNV: p.L206F .
NCIH1793 SNV: p.Q114R .
SW1116 SNV: p.A213P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C97(1.33)  LDD3380  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2780 C97(1.68)  LDD2254  [1]
 LDCM0023  KB03 A2780 C97(3.73)  LDD2671  [1]
 LDCM0024  KB05 OV-90 C97(1.33)  LDD3380  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840