General Information of Target

Target ID LDTP14558
Target Name Immunoglobulin kappa variable 3-15 (IGKV3-15)
Gene Name IGKV3-15
Synonyms
Immunoglobulin kappa variable 3-15; Ig kappa chain V-III region CLL; Ig kappa chain V-III region POM
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRLPAQLLGLLMLWVPGSSEDIVMTQTPLSLPVTPGEPASISCRSSQSLLDSDDGNTYLD
WYLQKPGQSPQLLIYTLSYRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQRIEF
P
Target Bioclass
Immunoglobulin
Subcellular location
Secreted
Function
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.
Uniprot ID
P01624
Ensemble ID
ENST00000390252.2
HGNC ID
HGNC:5816

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C46(0.80)  LDD3370  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 JeKo-1 C46(2.02)  LDD2403  [1]
 LDCM0023  KB03 JeKo-1 C46(2.57)  LDD2820  [1]
 LDCM0024  KB05 OCI-AML-2 C46(0.80)  LDD3370  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840