Details of the Target

General Information of Target

Target ID LDTP14527
Target Name Serine protease 23 (PRSS23)
Gene Name PRSS23
Gene ID 11098
Synonyms
ZSIG13; Serine protease 23; EC 3.4.21.-; Putative secreted protein Zsig13
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPEHCAPFRVGPAPGPYVASGDEPPGPQGTPAAAPHLHPAPPRGPRLTRFPACGPLEPY
LPEPAKPPAKYLQDLGPGPALNGGHFYEGPAEAEEKTSKAASFPQLPLDCRGGPRDGPSN
LQGSPGPCLASLHLPLSPGLPDSMELAKNKSKKRRNRTTFSTFQLEELEKVFQKTHYPDV
YAREQLALRTDLTEARVQVWFQNRRAKWRKRERYGKIQEGRNPFTAAYDISVLPRTDSHP
QLQNSLWASPGSGSPGGPCLVSPEGIPSPCMSPYSHPHGSVAGFMGVPAPSAAHPGIYSI
HGFPPTLGGHSFEPSSDGDYKSPSLVSLRVKPKEPPGLLNWTT
Target Bioclass
Enzyme
Family
Peptidase S1 family
Subcellular location
Secreted
Uniprot ID
O95084
Ensemble ID
ENST00000280258.6
HGNC ID
HGNC:14370

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.T45A .
BXPC3 SNV: p.E382D .
FUOV1 SNV: p.L171I DBIA    Probe Info 
NCIH1792 SNV: p.F12C .
OVCAR5 SNV: p.R204Ter DBIA    Probe Info 
SUPT1 Insertion: p.G141WfsTer60 .
SW1573 SNV: p.Q344Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K270(2.67); K189(2.74); K185(2.74); K331(4.02)  LDD3494  [1]
DBIA
 Probe Info  		C176(2.17); C370(3.18)  LDD3310  [2]
IPM
 Probe Info  		C380(0.72)  LDD1701  [3]
Acrolein
 Probe Info  		N.A.  LDD0232  [4]
IA-alkyne
 Probe Info  		C160(0.00); C176(0.00); C380(0.00); C370(0.00)  LDD0162  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C176(1.11)  LDD1507  [7]
 LDCM0276  AC17 HEK-293T C176(1.02)  LDD1515  [7]
 LDCM0285  AC25 HEK-293T C176(0.92)  LDD1524  [7]
 LDCM0294  AC33 HEK-293T C176(1.00)  LDD1533  [7]
 LDCM0303  AC41 HEK-293T C176(1.11)  LDD1542  [7]
 LDCM0311  AC49 HEK-293T C176(1.03)  LDD1550  [7]
 LDCM0320  AC57 HEK-293T C176(1.05)  LDD1559  [7]
 LDCM0356  AKOS034007680 HEK-293T C176(1.08)  LDD1570  [7]
 LDCM0632  CL-Sc Hep-G2 C176(20.00)  LDD2227  [6]
 LDCM0404  CL17 HEK-293T C176(1.19)  LDD1608  [7]
 LDCM0417  CL29 HEK-293T C176(0.99)  LDD1621  [7]
 LDCM0431  CL41 HEK-293T C176(0.99)  LDD1635  [7]
 LDCM0440  CL5 HEK-293T C176(1.08)  LDD1644  [7]
 LDCM0444  CL53 HEK-293T C176(1.12)  LDD1647  [7]
 LDCM0457  CL65 HEK-293T C176(1.10)  LDD1660  [7]
 LDCM0470  CL77 HEK-293T C176(1.13)  LDD1673  [7]
 LDCM0483  CL89 HEK-293T C176(1.08)  LDD1686  [7]
 LDCM0022  KB02 22RV1 C370(2.29)  LDD2243  [2]
 LDCM0023  KB03 MDA-MB-231 C380(0.72)  LDD1701  [3]
 LDCM0024  KB05 COLO792 C176(2.17); C370(3.18)  LDD3310  [2]
 LDCM0109  NEM HeLa N.A.  LDD0232  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Signal peptidase complex catalytic subunit SEC11C (SEC11C) Peptidase S26B family Q9BY50

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402