Details of the Target

General Information of Target

Target ID LDTP14515
Target Name Keratin, type I cuticular Ha3-I (KRT33A)
Gene Name KRT33A
Gene ID 3883
Synonyms
HHA3-I; HKA3A; KRTHA3A; Keratin, type I cuticular Ha3-I; Hair keratin, type I Ha3-I; Keratin-33A; K33A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMIKKNASSEDFFILLGFSNWPQLEVVLFVVILIFYLMTLTGNLFIIILSYVDSHLHTPM
YFFLSNLSFLDLCHTTSSIPQLLVNLRGPEKTISYAGCMVQLYFVLALGIAECVLLVVMS
YDRYVAVCRPLHYTVLMHPRFCHLLAAASWVIGFTISALHSSFTFWVPLCGHRLVDHFFC
EVPALLRLSCVDTHANELTLMVMSSIFVLIPLILILTAYGAIARAVLSMQSTTGLQKVFR
TCGAHLMVVSLFFIPVMCMYLQPPSENSPDQGKFIALFYTVVTPSLNPLIYTLRNKHVKG
AAKRLLGWEWGK
Target Bioclass
Other
Family
Intermediate filament family
Uniprot ID
O76009
Ensemble ID
ENST00000007735.4
HGNC ID
HGNC:6450

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C393(2.12)  LDD3331  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 MKN-1 C393(1.99)  LDD2497  [1]
 LDCM0023  KB03 JHH-7 C393(6.02)  LDD2824  [1]
 LDCM0024  KB05 MKN-1 C393(2.12)  LDD3331  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840