Details of the Target

General Information of Target

Target ID LDTP14508
Target Name Ras association domain-containing protein 9 (RASSF9)
Gene Name RASSF9
Gene ID 9182
Synonyms
PAMCI; PCIP1; Ras association domain-containing protein 9; PAM COOH-terminal interactor protein 1; P-CIP1; Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDTIFLWSLLLLFFGSQASRCSAQKNTEFAVDLYQEVSLSHKDNIIFSPLGITLVLEMVQ
LGAKGKAQQQIRQTLKQQETSAGEEFFVLKSFFSAISEKKQEFTFNLANALYLQEGFTVK
EQYLHGNKEFFQSAIKLVDFQDAKACAEMISTWVERKTDGKIKDMFSGEEFGPLTRLVLV
NAIYFKGDWKQKFRKEDTQLINFTKKNGSTVKIPMMKALLRTKYGYFSESSLNYQVLELS
YKGDEFSLIIILPAEGMDIEEVEKLITAQQILKWLSEMQEEEVEISLPRFKVEQKVDFKD
VLYSLNITEIFSGGCDLSGITDSSEVYVSQVTQKVFFEINEDGSEAATSTGIHIPVIMSL
AQSQFIANHPFLFIMKHNPTESILFMGRVTNPDTQEIKGRDLDSL
Target Bioclass
Other
Subcellular location
Endosome
Function May play a role in regulating vesicuar trafficking in cells.
Uniprot ID
O75901
Ensemble ID
ENST00000361228.5
HGNC ID
HGNC:15739

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C41(3.01)  LDD3380  [1]
1d-yne
 Probe Info  		N.A.  LDD0358  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2780 C41(1.87)  LDD2254  [1]
 LDCM0023  KB03 A2780 C41(2.66)  LDD2671  [1]
 LDCM0024  KB05 OV-90 C41(3.01)  LDD3380  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.