Details of the Target

General Information of Target

Target ID LDTP14500
Target Name C-type lectin domain family 3 member A (CLEC3A)
Gene Name CLEC3A
Gene ID 10143
Synonyms
CLECSF1; C-type lectin domain family 3 member A; C-type lectin superfamily member 1; Cartilage-derived C-type lectin
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MNRHLCVWLFRHPSLNGYLQCHIQLHSHQFRQIHLDTRLQVFRQNRNCILHLLSKNWSRR
YCHQDTKMLWKHKALQKYMENLSKEYQTLEQCLQHIPVNEENRRSLNRRHAELAPLAAIY
QEIQETEQAIEELESMCKSLNKQDEKQLQELALEERQTIDQKINMLYNELFQSLVPKEKY
DKNDVILEVTAGRTTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPADYGGLHHAAA
RISGDGVYKHLKYEGGIHRVQRIPEVGLSSRMQRIHTGTMSVIVLPQPDEVDVKLDPKDL
RIDTFRAKGAGGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQI
IEKDKRQQQSARKLQVGTRAQSERIRTYNFTQDRVSDHRIAYEVRDIKEFLCGGKGLDQL
IQRLLQSADEEAIAELLDEHLKSAK
Target Bioclass
Other
Subcellular location
Secreted
Function Promotes cell adhesion to laminin-332 and fibronectin.
Uniprot ID
O75596
Ensemble ID
ENST00000299642.10
HGNC ID
HGNC:2052

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C78(3.42); C68(3.36); C183(3.42)  LDD2268  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 BRX211 C78(3.42); C68(3.36); C183(3.42)  LDD2268  [1]
 LDCM0023  KB03 BRX211 C78(6.43); C68(6.33); C183(5.64)  LDD2685  [1]
 LDCM0024  KB05 BRX211 C78(5.12); C68(5.25); C183(4.75)  LDD3102  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840