Details of the Target

General Information of Target

Target ID LDTP14496
Target Name Zinc finger protein 254 (ZNF254)
Gene Name ZNF254
Gene ID 9534
Synonyms
BMZF5; ZNF539; ZNF91L; Zinc finger protein 254; Bone marrow zinc finger 5; BMZF-5; Hematopoietic cell-derived zinc finger protein 1; HD-ZNF1; Zinc finger protein 539; Zinc finger protein 91-like
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFLSAVFFAKSKSKNILVRMVSEAGTGFCFNTKRNRLREKLTLLHYDPVVKQRVLFVEKK
KIRSL
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
O75437
Ensemble ID
ENST00000357002.5
HGNC ID
HGNC:13047

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.L657V .
CORL23 SNV: p.A526G .
EFO21 SNV: p.E82V .
IGROV1 SNV: p.W95Ter .
MCF7 SNV: p.H620N .
MEWO SNV: p.F359Y .
NCIH23 SNV: p.T616S .
SW1271 Substitution: p.T177L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-465
 Probe Info  		K292(0.00); K295(0.00); Y294(0.00)  LDD2240  [1]

References

1 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010