Details of the Target

General Information of Target

Target ID LDTP14492
Target Name Breast carcinoma-amplified sequence 1 (BCAS1)
Gene Name BCAS1
Gene ID 8537
Synonyms
AIBC1; NABC1; Breast carcinoma-amplified sequence 1; Amplified and overexpressed in breast cancer; Novel amplified in breast cancer 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAEADGPLKRLLVPILLPEKCYDQLFVQWDLLHVPCLKILLSKGLGLGIVAGSLLVKLP
QVFKILGAKSAEGLSLQSVMLELVALTGTMVYSITNNFPFSSWGEALFLMLQTITICFLV
MHYRGQTVKGVAFLACYGLVLLVLLSPLTPLTVVTLLQASNVPAVVVGRLLQAATNYHNG
HTGQLSAITVFLLFGGSLARIFTSIQETGDPLMAGTFVVSSLCNGLIAAQLLFYWNAKPP
HKQKKAQ
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Required for myelination.
Uniprot ID
O75363
Ensemble ID
ENST00000395961.7
HGNC ID
HGNC:974

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C471(1.52)  LDD3389  [1]
WYneN
 Probe Info  		N.A.  LDD0021  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C471(0.97); C525(0.71); C343(0.67); C343(0.67)  LDD2227  [3]
 LDCM0022  KB02 AU565 C388(1.50)  LDD2265  [1]
 LDCM0023  KB03 AU565 C388(0.96)  LDD2682  [1]
 LDCM0024  KB05 OZ C471(1.52)  LDD3389  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264