Details of the Target

General Information of Target

Target ID LDTP14476
Target Name Tudor domain-containing protein 6 (TDRD6)
Gene Name TDRD6
Gene ID 221400
Synonyms
Tudor domain-containing protein 6; Antigen NY-CO-45; Cancer/testis antigen 41.2; CT41.2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSTSTSCPIPGGRDQLPDCYSTTPGGTLYATTPGGTRIIYDRKFLLECKNSPIARTPPCC
LPQIPGVTTPPTAPLSKLEELKEQETEEEIPDDAQFEMDI
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Tudor domain-containing protein involved in germ cell development, more specifically the formation of chromatoid body (during spermiogenesis), Balbiani body (during oogenesis), germ plasm (upon fertilization), and for proper miRNA expression and spliceosome maturation. Essential for RNA-dependent helicase UPF1 localization to chromatoid body, for UPF1-UPF2 and UPF1-DDX4 interactions which are required for mRNA degradation, using the extended 3' UTR-triggered nonsense-mediated mRNA decay (NMD) pathway. Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through interaction with arginine N-methyltransferase PRMT5 and symmetrically arginine dimethylated SNRPB (small nuclear ribonucleoprotein-associated protein).
Uniprot ID
O60522
Ensemble ID
ENST00000316081.11
HGNC ID
HGNC:21339

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO829 SNV: p.L602V .
DEL SNV: p.T251M .
EFO27 SNV: p.R584S .
G402 SNV: p.E933K .
G415 SNV: p.G761A .
HCT116 SNV: p.T1192I .
HCT15 SNV: p.K658R; p.N1367K .
HT SNV: p.V180A .
HT115 SNV: p.F1995L .
HT3 SNV: p.A477D .
IGROV1 SNV: p.Q708Ter .
Ishikawa (Heraklio) 02 ER SNV: p.V250M .
KATOIII SNV: p.V1927A .
KYSE150 SNV: p.D1661Y .
LS180 SNV: p.N1782T .
MCAS SNV: p.Q1455Ter .
MCC13 SNV: p.P370L
Substitution: p.P1922F		 .
MDAMB453 SNV: p.L1684F; p.Q2019H .
MEWO SNV: p.P1364S; p.P1633S; p.G2055E .
MFE319 SNV: p.E42K .
NALM6 SNV: p.R229Ter .
NCIH1299 SNV: p.E101G .
NCIH2172 SNV: p.R48L .
NCIH23 SNV: p.E1556G .
OVK18 SNV: p.S969P .
REC1 SNV: p.A1619P .
RKO SNV: p.Q1630H .
SUPT1 Insertion: p.V224GfsTer73 .
SW1990 SNV: p.A61T .
SW480 SNV: p.A491T; p.P1108L .
TOV21G SNV: p.S19Y; p.D22E; p.Q790R .
U2OS SNV: p.Q1228H .

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [1]

References

1 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.