Details of the Target

General Information of Target

Target ID LDTP14472
Target Name Protocadherin gamma-A12 (PCDHGA12)
Gene Name PCDHGA12
Gene ID 26025
Synonyms
CDH21; FIB3; KIAA0588; Protocadherin gamma-A12; PCDH-gamma-A12; Cadherin-21; Fibroblast cadherin-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAKLETLPVRADPGRDPLLAFAPRPSELGPPDPRLAMGSVGSGVAHAQEFAMKSVGTRTG
GGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLANSLYLNGELRGSDHTDVCGNVVGSSG
GSSSSGGSDKAPPQYREPSHPPKLLATSGKLDQCSEPLVRPSAFKPVVPKNFHSMQNLCP
PQTNGTPEGRQGPGGLKGGLDKSRTMTPAGGSGSGLSDSGRNSLTSLPTYSSSYSQHLAP
LSASTSHINRIGTASYGSGSGGSSGGGSGYQDLGTSDSGRASSKSGSSSSMGRPGHLGSG
EGGGGGLPFAACSPPSPSALIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAW
ERELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDK
VAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREG
RASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDE
AKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAE
ERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKAW
TPSRLERIESTEI
Target Bioclass
Other
Subcellular location
Cell membrane
Function Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Uniprot ID
O60330
Ensemble ID
ENST00000252085.4
HGNC ID
HGNC:8699

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.V626A .
DU145 SNV: p.M110I; p.S417R .
DU4475 SNV: p.T623M .
HCT15 SNV: p.R151W .
HEC1 SNV: p.P614L .
HEC1B SNV: p.A367V; p.P614L .
HGC27 SNV: p.G27R .
HUH28 SNV: p.A698S .
IGROV1 SNV: p.L714F; p.P736L .
LNCaP clone FGC SNV: p.A602V .
MCC13 SNV: p.P174L; p.S502L .
MEWO SNV: p.S509F; p.P771L .
NCIH1155 SNV: p.R92W .
NCIH196 SNV: p.V64F .
NCIH1993 SNV: p.A243S .
NCIH716 SNV: p.V646G .
ONS76 SNV: p.G620V .
REH SNV: p.A424T .
SISO SNV: p.R227G .
SNGM SNV: p.S500N .
SUPT1 SNV: p.A637T .
T24 SNV: p.R282Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		N.A.  LDD2223  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264