Details of the Target

General Information of Target

Target ID LDTP14455
Target Name Voltage-gated potassium channel subunit beta-3 (KCNAB3)
Gene Name KCNAB3
Gene ID 9196
Synonyms
KCNA3B; Voltage-gated potassium channel subunit beta-3; EC 1.1.1.-; K(+) channel subunit beta-3; Kv-beta-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATASPAADGGRGRPWEGGLVSWPPAPPLTLPWTWMGPSWGQHPGHWGFPALTEPSASPA
AGLGIFEVRRVLDASGCSMLAPLQTGAARFSSYLLSRARKVLGSHLFSPCGVPEFCSIST
RKLAAHGFGASMAAMVSFPPQRYHYFLVLDFEATCDKPQIHPQEIIEFPILKLNGRTMEI
ESTFHMYVQPVVHPQLTPFCTELTGIIQAMVDGQPSLQQVLERVDEWMAKEGLLDPNVKS
IFVTCGDWDLKVMLPGQCQYLGLPVADYFKQWINLKKAYSFAMGCWPKNGLLDMNKGLSL
QHIGRPHSGIDDCKNIANIMKTLAYRGFIFKQTSKPF
Target Bioclass
Transporter and channel
Family
Shaker potassium channel beta subunit family
Subcellular location
Cytoplasm
Function Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5.
Uniprot ID
O43448
Ensemble ID
ENST00000303790.3
HGNC ID
HGNC:6230

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C304(31.07)  LDD0209  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0023  KB03 Jurkat C304(31.07)  LDD0209  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GDP-mannose 4,6 dehydratase (GMDS) NAD(P)-dependent epimerase/dehydratase family O60547
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.