Details of the Target

General Information of Target

Target ID LDTP14452
Target Name Zinc finger protein 208 (ZNF208)
Gene Name ZNF208
Gene ID 7757
Synonyms
ZNF91L; Zinc finger protein 208; Zinc finger protein 91-like
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADKEAGGSDGPRETAPTSAYSSPARSLGDTGITPLSPSHIVNDTDSNVSEQQSFLVVVA
VDFGTTSSGYAYSFTKEPECIHVMRRWEGGDPGVSNQKTPTTILLTPERKFHSFGYAARD
FYHDLDPNEAKQWLYLEKFKMKLHTTGDLTMDTDLTAANGKKVKALEIFAYALQYFKEQA
LKELSDQAGSEFENSDVRWVITVPAIWKQPAKQFMRQAAYQAGLASPENSEQLIIALEPE
AASIYCRKLRLHQMIELSSKAAVNGYSGSDTVGAGFTQAKEHIRRNRQSRTFLVENVIGE
IWSELEEGDKYVVVDSGGGTVDLTVHQIRLPEGHLKELYKATGGPYGSLGVDYEFEKLLY
KIFGEDFIEQFKIKRPAAWVDLMIAFESRKRAAAPDRTNPLNITLPFSFIDYYKKFRGHS
VEHALRKSNVDFVKWSSQGMLRMSPDAMNALFKPTIDSIIEHLRDLFQKPEVSTVKFLFL
VGGFAEAPLLQQAVQAAFGDQCRIIIPQDVGLTILKGAVLFGLDPAVIKVRRSPLTYGVG
VLNRYVEGKHPPEKLLVKDGTRWCTDVFDKFISADQSVALGELVKRSYTPAKPSQLVIVI
NIYSSEHDNVSFITDPGVKKCGTLRLDLTGTSGTAVPARREIQTLMQFGDTEIKATAIDI
ATSKSVKVGIDFLNY
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
O43345
Ensemble ID
ENST00000397126.9
HGNC ID
HGNC:12999

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
786O Deletion: p.E1228DfsTer17 .
AN3CA SNV: p.N787S .
COLO678 SNV: p.G59R .
COLO800 SNV: p.E1116K .
COLO829 SNV: p.H855Y .
CORL88 SNV: p.W564L .
HCT15 SNV: p.E198V .
HGC27 SNV: p.T625P .
HT SNV: p.K479N .
K562 SNV: p.K1188N .
KASUMI2 SNV: p.T822A .
KATOIII SNV: p.K778Ter .
KMRC3 SNV: p.V1245I .
KYSE30 SNV: p.E893Q .
KYSE410 SNV: p.E1116K .
MDST8 SNV: p.R517K .
MELHO SNV: p.H935Q .
MEWO SNV: p.E288K; p.H1219Y .
MOLT4 SNV: p.A825V; p.V1267D .
NCIH1155 SNV: p.C318Y .
NCIH1703 SNV: p.C527F .
NCIH1793 SNV: p.C866W .
NCIH2172 SNV: p.G559D .
ONS76 SNV: p.K488E .
PANC0403 SNV: p.P888S .
REC1 SNV: p.G1203V .
RL952 Deletion: p.F932LfsTer62 .
SHP77 SNV: p.F1268C .
SW1271 SNV: p.C611Ter .
SW480 SNV: p.C183F .
UACC257 SNV: p.H307Y .
WM115 SNV: p.G1277E .
WM2664 SNV: p.G1277E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-465
 Probe Info  		K367(0.00); K370(0.00); Y369(0.00)  LDD2240  [1]

References

1 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010