Details of the Target

General Information of Target

Target ID LDTP14436
Target Name Tripartite motif-containing protein 66 (TRIM66)
Gene Name TRIM66
Gene ID 9866
Synonyms
C11orf29; KIAA0298; Tripartite motif-containing protein 66
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVTRFLGPRYRELVKNWVPTAYTWGAVGAVGLVWATDWRLILDWVPYINGKFKKDN
Target Bioclass
Other
Subcellular location
Nucleus
Function
May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association.
Uniprot ID
O15016
HGNC ID
HGNC:29005
ChEMBL ID
CHEMBL4296267

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C1254(0.92)  LDD2227  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C1254(0.92)  LDD2227  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264