General Information of Target

Target ID LDTP14419
Target Name Putative P2Y purinoceptor 10 (P2RY10)
Gene Name P2RY10
Gene ID 27334
Synonyms
Putative P2Y purinoceptor 10; P2Y10; P2Y-like receptor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDLWNWDEASPQEVPPGNKLAGLEGAKLGFCFPDLALQGDTPTATAETCWKGTSSSLASF
PQLDWGSALLHPEVPWGAEPDSQALPWSGDWTDMACTAWDSWSGASQTLGPAPLGPGPIP
AAGSEGAAGQNCVPVAGEATSWSRAQAAGSNTSWDCSVGPDGDTYWGSGLGGEPRTDCTI
SWGGPAGPDCTTSWNPGLHAGGTTSLKRYQSSALTVCSEPSPQSDRASLARCPKTNHRGP
IQLWQFLLELLHDGARSSCIRWTGNSREFQLCDPKEVARLWGERKRKPGMNYEKLSRGLR
YYYRRDIVRKSGGRKYTYRFGGRVPSLAYPDCAGGGRGAETQ
Target Type
Literature-reported
Target Bioclass
GPCR
Family
G-protein coupled receptor 1 family
Subcellular location
Cell membrane
Function Putative receptor for purines coupled to G-proteins.
TTD ID
T00488
Uniprot ID
O00398
DrugMap ID
TTMFOU6
Ensemble ID
ENST00000171757.3
HGNC ID
HGNC:19906
ChEMBL ID
CHEMBL3562166

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C29(1.94)  LDD3311  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C29(1.69)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C29(2.08)  LDD2660  [1]
 LDCM0024  KB05 G361 C29(1.94)  LDD3311  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840