Details of the Target

General Information of Target

Target ID LDTP14409
Target Name Transcriptional regulator SEHBP (ZNF689)
Gene Name ZNF689
Synonyms
Transcriptional regulator SEHBP; Short ORF-encoded histone-binding protein; ZNF689 upstream open reading frame protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARAGARGLLGGRRPPGLRLALALRLALLLARPPSGRAGAPEAQGPAAPGTTAPEGGDRC
RGYYDVMGQWDPPFNCSSGAYSFCCGTCGYRFCCHDGPRRLDQSRCSNYDTPAWVQTGRP
PARARDTAAPRDPGRERSHTAVYAVCGVAALLVLAGIGARLGLERAHSPRARRTVTRALT
ELLKQPGPQEPLPPTLGPPLGGCVQVQMGDGLPRGSPHNSADKKRLNNAPRGSAAPGPPR
GPRLQGGGSLTLQPDYAKYATFKAAALKAAEAAPRDFCQRFPALEPSPRQPPARAPRPSP
DLPAPLDACPWAPPVYAPPAAPGPYAAWTSSRPARPAPLSHPTARAFQVPRRPGHAARRQ
FSVKMPETFNPQLPGLYGSAGRGSRYLRTNSKTEVTV
Target Bioclass
Other
Subcellular location
Nucleus
Function Plays a role in transcription regulation.
Uniprot ID
C0HLU2
HGNC ID
HGNC:25173

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C484(1.47)  LDD3317  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A101D C484(2.10)  LDD2250  [1]
 LDCM0023  KB03 A101D C484(2.70)  LDD2667  [1]
 LDCM0024  KB05 MEL182 C484(1.47)  LDD3317  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840