Details of the Target

General Information of Target

Target ID LDTP14407
Target Name Protein shisa-9 (SHISA9)
Gene Name SHISA9
Gene ID 729993
Synonyms
Protein shisa-9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLGGLGKLAAEGLAHRTEKATEGAIHAVEEVVKEVVGHAKETGEKAIAEAIKKAQESGDK
KMKEITETVTNTVTNAITHAAESLDKLGQ
Target Bioclass
Transporter and channel
Family
Shisa family, SHISA9 subfamily
Subcellular location
Cell projection, dendritic spine membrane
Function
Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses.
Uniprot ID
B4DS77
Ensemble ID
ENST00000423335.2
HGNC ID
HGNC:37231

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.M235V .
CCLP1 SNV: p.H325Q .
CCSW1 SNV: p.L324V .
COLO679 SNV: p.E265K .
COLO792 Substitution: p.G401K .
IGR1 SNV: p.S285F .
Ishikawa (Heraklio) 02 ER SNV: p.I211T .
LS180 SNV: p.V215A .
NCIH2286 Insertion: p.M235DfsTer31 .
REH SNV: p.P333S .
RL952 SNV: p.K319N .
SG231 SNV: p.L400F .
SHSY5Y SNV: p.V291L .
WM115 SNV: p.G401E .
WM2664 SNV: p.G401E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C200(1.24)  LDD3383  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2780 C200(1.51)  LDD2254  [1]
 LDCM0023  KB03 A2780 C200(1.66)  LDD2671  [1]
 LDCM0024  KB05 OVCAR-5 C200(1.24)  LDD3383  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840