Details of the Target

General Information of Target

Target ID LDTP14405
Target Name Laforin, isoform 9 (EPM2A)
Gene Name EPM2A
Synonyms
Laforin, isoform 9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASNVTNKMDPHSVNSRVFIGNLNTLVVKKSDVEAIFSKYGKIAGCSVHKGFAFVQYDKE
KNARAAVAGEDGRMIASQVAVINLAAEPKVNRGNAGVKRSAAEMYGSSFDLDYGFQRDYY
DGMYSFPARVPPPPPIALAVVPSKRQRISGNTSRRGKSGFNSKSGKRGSSKSGKLKGDDL
QAIKQELTQIKQKVDSLLENLEKIEKEQSKQEVEVKNAKSEEEQSSSSMKKDETHVKMES
EGGAEDSAEEGDPLDDDDNEDQGDNQLHLIKNNEKDAEEGEDNRDSTNGQDDS
Target Bioclass
Other
Subcellular location
Nucleus
Uniprot ID
B3EWF7
HGNC ID
HGNC:3413

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C86(2.82)  LDD3331  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 IPC-298 C86(1.98)  LDD2400  [1]
 LDCM0023  KB03 IPC-298 C86(1.95)  LDD2817  [1]
 LDCM0024  KB05 MKN-1 C86(2.82)  LDD3331  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840